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卫生部办公厅关于印发《基孔肯雅热诊断和治疗方案》的通知


  基孔肯雅热的预防主要采取以下措施。

  (一)控制传染源。

  尽量就地治疗,以减少传播机会。患者在病毒血症期间,应予以防蚊隔离。隔离期为发病后5天。发现疑似和确诊病例应及时上报。

  (二)切断传播途径。

  病室中应有蚊帐、纱窗、纱门等防蚊设备。消灭蚊虫和清除蚊虫孳生地。

  (三)保护易感人群。

  目前尚无可供使用的疫苗。主要采取个人防蚊措施。

  附件2
  参考文献

  1.Ross RW. The Newala epidemic. Ⅲ. The virus: isolation, pathogenic properties and relationship to the epidemic. J Hyg(Lond), 1956,54: 177-191.

  2.Powers AM, Brault AC, Tesh RB, et al. Re-emergence of chikungunya and o’nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships. J Gen Virol, 2000, 81: 471-479.

  3.Strauss JH, Strauss EG. Viruses and human diseases. California: Academic Press, 2002: 76-85.

  4.Schuffenecker I, Iteman I, Michault A, et al. Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak. PLoS Med, 2006, 3: e263.

  5.Khan AH, Morita K, Parquet M del C, et al. Complete nucleotide sequence of chikungunya virus and evidence for an internal polyadenylation site. J Gen Virol, 2002, 83: 3075-3084.

  6.Sourisseau M, Schilte C, Casartelli N, et al. Characterization of reemerging chikungunya virus. PLoS Pathog, 2007, 3: e89.

  7.Yada JS. A special issue on chikungunya. ENVIS News Letter, Issue 2, 2006, 3: 1-12.

  8.Couderc T, Chrétien F, Schilte C, et al. A mouse model for chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog, 2008, 4: e29.

  9.Lee N, Wong CK, Lam WY, et al. Chikungunya fever, Hong Kong. Emerg Infect Dis 2006, 12: 1790-1792.

  10.Saxena SK. Re-emergence of the knotty chikungunya virus: facts, fear or fiction. Future Virol, 2007, 2: 121-126.


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